Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
2001 2
2002 3
2003 4
2004 3
2005 9
2006 10
2007 9
2008 9
2009 12
2010 15
2011 30
2012 34
2013 30
2014 38
2015 34
2016 20
2017 20
2018 25
2019 25
2020 30
2021 21
2022 8
2023 11
2024 6

Text availability

Article attribute

Article type

Publication date

Search Results

354 results

Results by year

Filters applied: . Clear all
Page 1
Impact of OATP transporters on pharmacokinetics.
Kalliokoski A, Niemi M. Kalliokoski A, et al. Br J Pharmacol. 2009 Oct;158(3):693-705. doi: 10.1111/j.1476-5381.2009.00430.x. Epub 2009 Sep 25. Br J Pharmacol. 2009. PMID: 19785645 Free PMC article. Review.
Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on the sinusoidal membrane of hepatocytes and can facilitate the liver uptake of their substrate drugs. OATP1A2 is expressed on the luminal membrane of small intestinal enterocytes and at the blo …
Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on the sinusoidal membrane of hepatocytes and can facilitate t …
Transcriptome analysis of healthy and fatty liver revealed that inhibition of SLCO1B3 induces abnormal liver metabolism and lipid synthesis.
Zhu X, Chen Y, Lan T, Liu C. Zhu X, et al. Poult Sci. 2023 Nov;102(11):103023. doi: 10.1016/j.psj.2023.103023. Epub 2023 Aug 14. Poult Sci. 2023. PMID: 37748246 Free PMC article.
Our bioinformatics analysis of RNA-seq data revealed differential expression of SLCO1B3 in healthy liver and fatty liver, with lower ex-pression levels observed in fatty liver. ...These findings provide insight into the molecular mechanism of SLCO1B …
Our bioinformatics analysis of RNA-seq data revealed differential expression of SLCO1B3 in healthy liver and fatty liver …
Rotor Syndrome.
Jirsa M, Knisely AS, Schinkel A, Kmoch S. Jirsa M, et al. 2012 Dec 13 [updated 2019 Jul 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2012 Dec 13 [updated 2019 Jul 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 23236639 Free Books & Documents. Review.
DIAGNOSIS/TESTING: The diagnosis of Rotor syndrome is established in a proband with isolated, predominantly conjugated hyperbilirubinemia without cholestasis or liver injury and typical findings on cholescintigraphy. Identification of biallelic pathogenic variants in SLCO1 …
DIAGNOSIS/TESTING: The diagnosis of Rotor syndrome is established in a proband with isolated, predominantly conjugated hyperbilirubinemia wi …
An EAV-HP insertion in the promoter region of SLCO1B3 has pleiotropic effects on chicken liver metabolism based on the transcriptome and proteome analysis.
Chen J, Hua G, Han D, Zheng X, Dong X, Wang S, Long J, Zheng Z, Wang A, Wang J, Wang X, Deng X. Chen J, et al. Sci Rep. 2021 Apr 7;11(1):7571. doi: 10.1038/s41598-021-87054-9. Sci Rep. 2021. PMID: 33828143 Free PMC article.
We previously reported that an EAV-HP inserted mutation (IM+) in the 5' flanking region of SLCO1B3 was the causative mutation of chicken blue eggs, and a further research showed that IM+ significantly reduced the expression of SLCO1B3 in liver. ...We performe …
We previously reported that an EAV-HP inserted mutation (IM+) in the 5' flanking region of SLCO1B3 was the causative mutation of chic …
SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.
Cheng YY, Chang KC, Chen PL, Yeung CY, Liou BY, Chen HL. Cheng YY, et al. J Formos Med Assoc. 2023 Jul;122(7):648-652. doi: 10.1016/j.jfma.2023.03.003. Epub 2023 Mar 23. J Formos Med Assoc. 2023. PMID: 36964102 Free article.
We report five Taiwanese pediatric and adult patients aged 5-32 years presenting with conjugated hyperbilirubinemia, and were found to have genetic variants of SLCO1B1 and SLCO1B3. Two also had history of prolonged neonatal jaundice. Genetic analysis using panel-based next …
We report five Taiwanese pediatric and adult patients aged 5-32 years presenting with conjugated hyperbilirubinemia, and were found to have …
Structure of human drug transporters OATP1B1 and OATP1B3.
Ciută AD, Nosol K, Kowal J, Mukherjee S, Ramírez AS, Stieger B, Kossiakoff AA, Locher KP. Ciută AD, et al. Nat Commun. 2023 Sep 18;14(1):5774. doi: 10.1038/s41467-023-41552-8. Nat Commun. 2023. PMID: 37723174 Free PMC article.
The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane proteins that mediate uptake of drugs into the liver for subsequent conjugation and biliary excretion, a key step in drug elimination from the human body. ...
The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane proteins that mediate uptake of drugs into the liver for …
The Emerging Role of the SLCO1B3 Protein in Cancer Resistance.
Sun R, Ying Y, Tang Z, Liu T, Shi F, Li H, Guo T, Huang S, Lai R. Sun R, et al. Protein Pept Lett. 2020;27(1):17-29. doi: 10.2174/0929866526666190926154248. Protein Pept Lett. 2020. PMID: 31556849 Free PMC article. Review.
The solute carrier organic anion transporter family member 1B3 (SLCO1B3), a functional transporter normally expressed in the liver, transports a variety of endogenous and exogenous compounds, including hormones and their conjugates as well as some anticancer drugs. …
The solute carrier organic anion transporter family member 1B3 (SLCO1B3), a functional transporter normally expressed in the liver …
CYP2C9, SLCO1B1, SLCO1B3, and ABCB11 polymorphisms in patients with bosentan-induced liver toxicity.
Roustit M, Fonrose X, Montani D, Girerd B, Stanke-Labesque F, Gonnet N, Humbert M, Cracowski JL. Roustit M, et al. Clin Pharmacol Ther. 2014 Jun;95(6):583-5. doi: 10.1038/clpt.2014.42. Clin Pharmacol Ther. 2014. PMID: 24842639
Bosentan is an endothelin receptor antagonist used as a first-line treatment in pulmonary arterial hypertension (PAH). Its main adverse effect is a dose-dependent liver toxicity. CYP2C9*2 has recently been shown to be associated with hepatotoxicity in PAH patients. We cond …
Bosentan is an endothelin receptor antagonist used as a first-line treatment in pulmonary arterial hypertension (PAH). Its main adverse effe …
Impact of SLCO1B1*5 on Flucloxacillin and Co-Amoxiclav-Related Liver Injury.
Alshabeeb M, Alomar FA, Khan A. Alshabeeb M, et al. Front Pharmacol. 2022 Jun 8;13:882962. doi: 10.3389/fphar.2022.882962. eCollection 2022. Front Pharmacol. 2022. PMID: 35754504 Free PMC article.
Background: Idiosyncratic drug-induced liver injury (DILI) is a serious uncommon disease that may develop as a result of the intake of certain drugs such as the antimicrobials flucloxacillin and co-amoxiclav. ...The solute carrier organic anion transporter 1B1 (SLCO1B1), a …
Background: Idiosyncratic drug-induced liver injury (DILI) is a serious uncommon disease that may develop as a result of the intake o …
354 results